Striped mouse

Striped mouse

Striped mouse (Rhabdomys pumilio) on the cover of the August edition of Behaviour

Striped mouse (Rhabdomys pumilio) on the cover of the August edition of Behaviour
My photo and the accompanying paper (see List of publications) were published in this issue.

Monday, November 18, 2013

Summary: Padmanabhan et al. (2012)

Transcriptional feedback loops drive the functioning of eukaryotic circadian clocks. Two important mammalian proteins involved in this process are Period (PER) and Cryptochrome (CRY). These proteins aggregate and form large nuclear complexes (PER complex), suppressing their own transcription. Padmanabhan et al. (2012) found the RNA helicases DDX5 and DHX9 are included in the PER complexes of mice. In addition, other molecules, such as RNA polymerase II large subunit, were also located here, promoting the termination of transcription. They found that RNA polymerase II accumulates, during circadian negative feedback, near termination sites on Per and Cry genes, but it does not control these genes. They conclude that this negative feedback mechanism includes direct control of the termination of protein transcription.

No comments:

Post a Comment